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In a previous prospective cohort study of individuals who had mild COVID-19, it was found that approximately 25% of young adults (with an average age of 38 years) exhibited significant cognitive impairment in the copy stage of the Rey-Osterrieth Complex Figure (ROCF) Test four months after their recovery from the infection 4

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TABLE 1 Clinical summary of antioxidant intervention in ASD: Population, dose/route, duration, clinical domains, redox biomarkers, safety, and level of evidence are reported for each study

Further research is needed to elucidate the basic mechanism underpinning T and B-cell recruitment into an immune response, to examine antibody affinity maturation and to identify the determinants of the immunodominance hierarchy for T and B-cell epitopes, which ultimately may enable vaccine antigens to be rationally designed to induce broadly targeted immunity