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An additional possibility would be the transfer of haem-bound NO to a free thiol group

10.3390/ijms21041505 66 KapogiannisD.MattsonM

Vitamin B12 deficiency in the longer run can lead to nervous system disorders with sensation changes, loss of power or co-ordination, gut disorders and (rarely) dementia or mental illness

Maintaining adequate glutathione levels depends on the availability of glutamine and cysteine, two crucial amino acids needed for its synthesis

Weiss-Sadan T, Ge M, Hayashi M, Gohar M, Yao CH, De Groot A, Harry S, Carlin A, Fischer H, Shi L, Wei TY, Adelmann CH, Wolf K, Vornbaumen T, Durr BR, Takahashi M, Richter M, Zhang J, Yang TY, Vijay V, Fisher DE, Hata AN, Haigis MC, Mostoslavsky R, Bardeesy N, Papagiannakopoulos T, Bar-Peled L (2023) NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer