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44 , W90-97

Rosa tdTomato/+ mice were intraperitoneally injected with tamoxifen (10 mg/kg body weight) on days 0, 1, and 2 (12 h before isolation) to label Alpi+ lineages

They are now undergoing extensive research with human trials for potential use as part of the healthy aging process (Guarente et al 2024)

A University of Maryland future study is currently in the planning stages, which will seek to determine the impact of a longer KAT protocol on cancer stem cells and the metastatic spread of pancreatic cancer