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By dosage, the mean changes were: 500 mcg: 127% 750 mcg: 176% (single study) 1,000 mcg: 280% 1,500 mcg: 310% 2000 mcg: 260% 5,000 mcg: 62% While 1,500 mcg of vitamin B12 showed the highest average increase, the effect plateaued or declined at higher doses, suggesting a possible saturation of absorption pathways

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Standard cycles in this context typically run 8 to 12 weeks, with maximum continuous use up to 16 weeks and a 4 to 8 week break before any repeat cycle

While the liver has substantial storage capacity, supraphysiological doses (such as from injections) are largely excreted in the urine

Conclusion: Choosing the Right Approach for You Both vitamin B12 injections and oral supplements have their advantages and drawbacks, and the best option depends on your individual circumstances