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This approach, however, has several major limitations when applied to clinical coding: (1) Handling unseen, infrequent, and imbalanced labels: In the MIMIC-III data set, around 5000 codes appear fewer than 10 times in the training data and over 50% of codes never appear 37

If you get this book be sure to cover it or turn it face down when you leave it or youre going to hear people asking the question