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doi: 10.1016/0378-4274(95)03532-X 21 AndersonGJFrazerDM

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Rapamycin, a macrolide immunosuppressant generated by the bacterium Streptomyces hygroscopicus, impedes the transition of T cells from the G1 phase to the S phase of the cell cycle by inhibiting IL-2-mediated signaling pathways, thus exerting anti-inflammatory activity [260, 261]