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FIGURE 1 6 Key priorities for clinical transformation 6.1 Precise patient stratification based on metabolic classification Combined imagingmulti-omics markers can identify metabolic subtypes, such as high glycolysis/low lipid-droplet load (including DCCD)/glutamine dependence, which inform cohort stratification and efficacy prediction

Acknowledgements Financial Support: Fundao de Amparo Pesquisa do Estado de So Paulo - FAPESP (Grants 2005/51875-0 and 2007/55348-0 to TAP)

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