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Strategies such as vascular remodeling, stromal regulation, manipulation of hypoxia and pH, and reshaping the immune microenvironment present encouraging pathways to address barriers within the TME

Adams, E

Enhanced expression of mRNA for transforming growth factor-beta, type I and type III procollagen in human post-burn hypertrophic scar tissues

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To address this issue and to demonstrate the ability of validated targets to induce a synergistic immune response in intact tumors, tissue slice culture was performed