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Phytochemicals such as, the Resveratrol (3,4,5-trihydroxy stilbene) and the Curcuminoids (with , -unsaturated carbonyl groups) are potential inducers of HO-1 expression through Nrf2/ antioxidant-responsive element (ARE) pathway 471,472

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Taken together, current research has not only elucidated the multifaceted molecular mechanisms by which bile acids and their derivatives regulate lipid metabolism in subcutaneous and hepatic tissues, but emerging evidence also reveals a significant correlation between specific bile acid profiles and IMF deposition

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