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One study found older cigarette smokers had 1.8-fold less of a glutathione response to smoking compared with younger smokers

Cells were pre-treated with LPS (1 g/mL) for 30 min to induce an inflammatory state, followed by treatment with varying concentrations of APE (62.5, 125, 250, 500, 1000, and 2000 g/mL) for 24 h