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Folate monoglutamates compete very poorly with cellular folylpolyglutamates for the enzymes of one-carbon metabolism

All patients receive pre-medications of diphenhydramine (Benadryl), acetaminophen (Tylenol) and a small dose of steroids before the infusion to prevent an infusion reaction (see below)

Written informed consent was obtained from all participants before entry into the study

Remarkably, no substantial toxicity (~ 98% viable cells) to the cell was observed at lower concentrations (10100 g/mL)

Botox is also sometimes used as a treatment for certain medical problems including chronic migraines, excessive sweating, and TMJ disorders