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376 The causal role of oxidative damage in the ageing process remains controversial, partly because of the absence of a clear correlation between the efficacy of antioxidant defenses and extended cellular function or longevity

This phenomenon supports the notion that increased oxidative stress is an important pathogenic mechanism of HCC [2,3,5], and suggests that GSH might be utilized and oxidized to GSSG in order to cope with increased oxidative stress during the development of HCC

Rational drug design, which is the application of a structure-function relationship, is now widely used in modern medicinal chemistry for developing exquisitely selective ligands

In short, islets were incubated in 96-well plates with one islet per well for 23 days in a cell culture incubator in DMEM

doi: 10.3390/biom14020198 17