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This pathway is initiated by a combination of Patched and Hh proteins, consisting of Sonic Hh (Shh), Desert Hh, and Indian Hh (Ihh), which allows Smoothened to transmit signals to the nucleus

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Mitogen-activated protein kinases in apoptosis regulation

At this timepoint, DIO male and female mice had a slight reduction in detectable live virus (measured by PFU) compared to controls, although this was only statistically significant in males

Evaluation of compound 2 stability under the biochemical assay conditions with recombinant TGR TGR assay solutions (1 ml each) were prepared as described in the main manuscript