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176, 583593, Epub 2018 Aug 23

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The endothelium, a semipermeable layer, serves as a barrier between the bloodstream and the innermost lining of blood vessels

In the pivotal, phase 3, placebo-controlled RESPONSE trial (NCT04620733), seladelpar, a novel delpar (selective PPAR-delta agonist), led to a significantly higher percentage of PBC patients achieving the composite biochemical endpoint (ALP 0 U/L from baseline) and safety by baseline ALP subgroup were also evaluated