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We demonstrated specificity of the effect of acivicin, which decreases glutamate liberation from glutathione, by rescuing with pyrogluamate, the immediate metabolic precursor of glutamate in the glutathione cycle

This multilayered heterogeneity network necessitates that ferroptosis-targeted therapies adopt precise stratification strategies, integrating technologies such as single-cell sequencing and spatial metabolomics to identify sensitive subpopulations and implement targeted interventions

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A., Barlow, J