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IGF-1 is the real worker in this chain

Thus, ubiquitination shows a regulatory role in receptor-mediated mitophagy

10.1186/s12877-024-05392-5 331

AlphaFold predictions of complexes between NS3h, RNA and/or NS5B suggest that NS3h both remodels the cis-acting RNA elements and unwinds the terminal stem-loop of the HCV genome rendering the template accessible for de novo initiation of () strand synthesis by NS5B