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Western blot and immunofluorescence showed a pronounced reduction in SPP1 expression in HSCs from AAV6-SMA-sh Thbs2 mice

Kaludercic, N., Deshwal, S

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By harnessing the ability to modulate these erasers, it is anticipated that novel therapeutic strategies can be devised to regulate lactylation-associated diseases, including cancer, in the foreseeable future

The remaining two metabolites, SF-glucuronide and SF-sulfate, are produced by the bodys Phase 2 detoxification enzymes UDP glucuronidases (EC 2.4.1.17) and UDP-sulfotransferases (EC 2.8.2), respectively 63,64