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Nevertheless, the homozygote mutant genotype leads to hyperhomocysteinemia only when plasma folate status is low in healthy subjects and in patients with cardiovascular disease, thus subjects with this MTHFR mutation may be sensitive to low folate intake (Christensen et al, 1997

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Researchers found that a combination of topiramate and phentermine resulted in greater weight loss than either alone

The difference is subtle and does not indicate any chemical change

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