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Cytosolic malic enzyme normally only operates toward decarboxylation

This work was supported by: Swedish Cancer Society postdoctoral fellowship 21 0346 PT (A.M.), Royal Physiographic Society of Lund grants 2019-2023 (A.M.), Gyllenstiernska Krapperupstiftelsen grants 2021-2023 (A.M.), Gunnar Nilssons Cancer Foundation grants 2020-2023 (A.M.), Marta Winklers Foundation grant 2021-2022 (A.M.), Mary Beves Foundation grant 2021-2022 (A.M.), Maja och Halmar Leander Foundation grant 20202021 (A.M.), Swedish Childhood Cancer Foundation grant TJ2021-0068 (JTS), Swedish Childhood Cancer Foundation grant TJ2021-0137 and PR2021-0129 (O.C.B-R), KI Forskningsbidrag grant 2022-01925 (O.C.B-R), Swedish Cancer Society grant 23 2754 Pj (D.B.), Swedish Childhood Cancer Foundation grant PR2023-0006 (D.B.), Swedish Research Council grant 2021-02597 and 2023-02402 (D.B.), The Crafoord Foundation grant 20230504 (D.B.), Region Skne and Skne University Hospital Funding grant (D.B.)

Cinkilic N, Tzn E, etinta SK, Vatan , Ylmaz D, ava T, Tun S, zkan L, Bilalolu R

Moreover, ILDR enhances the efficacy of ICI through microbiota- and BA-mediated mechanisms, including increased DC activation and CD8+ T cell recruitment, potentially driven by DCA enrichment ( Together, these findings suggest that targeting the microbiotaBA axis may improve the efficacy and tolerability of chemoradiotherapy

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