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Curcumin reduces cardiac fibrosis by activating SIRT1, increasing NRF2 (Zeng et al., 2015), increasing NADPH oxidase subunits, weakening PKC-MAPK (Soetikno et al., 2012) signaling pathway, and reducing SOD and MDA (Sadoughi et al., 2021)

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Clinical trials offer increased access to newer medicines Referring PWH to clinical trials may not only help scientists better understand hypersomnias and their treatment, but it may allow PWH to try medicines that arent yet available in their home country nor approved for their diagnosis