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The spinal fluid of 27 schizophrenic patients had a significantly higher concentration of albumin and immunoglobulin compared to healthy people, indicating a disruption of the BBB [50]

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This suggests that the effects of second-generation antipsychotics on memory function may be due in part to increased brain levels of PREG and/or PregS (373)

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The structural data supports an ability of the bypass motif to transition between structured and unstructured conformations in the absence of the allosteric constraint from a RAMP protein