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On the other hand, several investigators found that treatment with erastin could inhibit system xCT, thereby reducing extracellular cystine import for GSH synthesis and increasing the sensitivity to ferroptosis (Wang et al., 2020)

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Drug Targets Summary Keywords retinal ganglion cells, optic neuropathy, endogenous neuroprotection, cell survival, stress-response Citation Pietrucha-Dutczak M, Amadio M, Govoni S, Lewin-Kowalik J and Smedowski A (2018) The Role of Endogenous Neuroprotective Mechanisms in the Prevention of Retinal Ganglion Cells Degeneration

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doi:10.1016/0014-5793(75)80279-1

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Conserved domain and motif of protein were analyzed by Pfam, MEME-CHIP, SMART and SCOP online tools [47,48,49,50]

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Aggregates of the mutant enzyme are also selectively found in the mitochondrial outer membrane in spinal cord from mouse models of ALS (Liu et al., 2004)

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