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Metformin can be used in individuals with heart failure, if the estimated glomerular filtration rate is stable and 30 mL/min/1.73 m [] and should be discontinued in unstable or hospitalized patients with HF

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Regarding helminth parasites anti-neoplastic activity against multiple myeloma, Tsocheva et al

suitable extraneous thiols include but are not limited to reduced glutathione, DODT, DTT, protein, sterically hindered thiols, and the like