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doi:10.1021/ja983173l 34

completed pivotal trials but investigational and not yet approved anywhere

Adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA) are the most commonly used animal models for the study of RA, and they are able to mimic the key features of RA, such as the abnormal proliferation of synovial tissues, swelling of the joints, and the destruction of cartilage and bone tissues (108)