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In addition to these roles, microglia are implicated in other processes during EBI, such as white matter injury, demyelination, and glutamate excitotoxicity, which leads to neuronal and glial cell death

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In addition, CHE significantly increased the protein and mRNA expressions of total p53/phospho-p53, which led to the induction of apoptosis by the p53 pathway, which was further confirmed by the p53 knockdown of DL cells (Kumar et al., 2015b)

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To demonstrate its efficacy as a standard therapeutic option, further controlled clinical trials are needed[137]