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In severe acute pancreatitis (SAP), inflammatory factors promote the expression of matrix metalloproteinases (MMPs) and heparinases, which degrade syndecan-1 (SDC-1) and HS, while oxidative stress disrupts HA-CD44 binding, leading to increased capillary leakage and neutrophil adhesion

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En modelos murinos de enfermedad inflamatoria intestinal, el tratamiento oral con BPC-157 se asocio con reduccion de la inflamacion colonica, cicatrizacion mucosa acelerada y mejora en las puntuaciones de actividad de la enfermedad