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Acute respiratory distress syndrome (ARDS) is considered as a decisive cause of death in COVID-19 disease (Gralinski and Baric, 2015

Pickarts original 1973 discovery actually centered on wound healing he observed that GHK accelerated liver regeneration in plasma at concentrations 1,000 times lower than other known healing promoters at the time

Moreover, standardized assays for oxidative stress and robust algorithms for personalized treatment remain in development

In vitro , purple sweet potato anthocyanins (PSPAs) activated NRF2 signaling pathway to enhance PINK1-Parkin-mediated mitophagy, attenuating Klebsiella pneumoniae (KP)-induced pyroptosis in alveolar macrophages, and in mice infected with KP, PSPA has been shown to alleviate lung injury and inflammatory responses [125]

Meanwhile, SIRT1 enhances mitochondrial function and promotes autophagy through the regulation of multiple metabolic genes (24)