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10.1371/journal.pone.0111899 27 JonesD

Research into the mechanisms of learning and memory not only is one of the central tasks of neuroscience but also is important for the development of new (and improvement of existing) therapeutic approaches to cognitive disorders as well as mood disorders because many psychiatric disorders involve disturbances of cognitive processes 6,7,8,9

BDNF plays a key role in plasticity of the brain including learning and memory (3)

However, two phase III clinical trials (NCT04669496, jRCTs031200388) are currently evaluating the combination of toripalimab (anti-PD1) with lenvatinib and gemcitabine-oxaliplatin or CisGem plus S-1, respectively, as neoadjuvant treatments prior to surgery

Conserved cell-type specific signature of resilience to Alzheimers disease nominates role for excitatory intratelencephalic cortical neurons