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3234 In a meta-analysis of pharmacotherapies used for cognitive and behavioral impairment, MPH was associated with reductions in anger and aggression and enhanced psychosocial function, whereas amantadine improved aberrant behavioral symptoms

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The signaling pathway responsible for these effects appears to be cAMP/PKA/CREB, which in this study was shown to be negatively regulated by both NESF and NLP ( Figure 9 )

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