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[Abstract]2019 Nov;121(8):151439

Oxidative stress is the state induced by an overbalance in the form of excess ROS, and can be a causative factor in chronic wound formation 15 , as well as in the pathogenesis of other diseases including cancers, cardiovascular diseases, Parkinsons, obesity, and other clinically-relevant age-related diseases 54,55,56,57

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In the first, a tolerable concentration (TC) was derived on the basis of division of an effect level for irritancy in the respiratory tract of rodents by an uncertainty factor, based on the principles outlined in WHO (in press) and the assumption that there is a threshold for acetaldehyde-induced cancer of the respiratory tract in rodents exposed via inhalation