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The protons generated from cytosolic lactic acid are immediately buffered in the cell or exported to the interstitial fluid and further transported to the blood

doi: 10.1152/jappl.1993.75.6.2419

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Because NPs differ widely in size, shape, material composition, and optical/electromagnetic properties [19], selecting an appropriate platform requires consideration of factors such as particle size for target access, carrier biocompatibility to reduce toxicity, and stability to prevent premature aggregation or degradation [19]

When challenged with oxidative stress, VRK2 knockdown led to more cell death compared to the negative control group, and the increase in cell death could be mitigated by Ferr-1 (Fig