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2023;59 doi: 10.1016/j.redox.2022.102568

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However, when cysteine residues are located near positively charged residues, their pKa decreases to less than 6.5, increasing their susceptibility to oxidation

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Experimental data shows that macrophages treated with TMAO can significantly increase the expression levels of IFN-, Ki-67, CD103, and CD44 in CD8 + and CD4 + T cells, indicating enhanced T cell activation and proliferation