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This combination functions through sophisticated regulation of cellular processes, promoting apoptosis of inflammatory cells while inhibiting excessive autophagy, and uniquely regulating the balance of pro-apoptotic and anti-apoptotic proteins [249]

This direct damage, along with metabolic disturbances and altered gene expression in cardiomyocytes induced by the inflammatory response, results in necrosis and apoptosis of cardiomyocytes (32)

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This indicates that rutin may enhance the toughness of retinal capillaries, diminish their permeability, and alleviate inflammatory stimuli on endothelial cells while preserving the integrity of the vascular wall (Palmitessa et al., 2022)

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