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Christen S, et al

Modulation by ozone therapy of oxidative stress in chemotherapy-induced peripheral neuropathy: the background for a randomized clinical trial

10.1039/c4ob02462a 134 YangJ.JiaL.HeZ.WangY

While the clinical significance of this in healthy adults is still being characterised, the theoretical concern about sustained supraphysiological IGF-1 and long-term tissue effects is the basis for the oncogenic risk concerns flagged in the long-term safety literature