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A.et al (2015)

It was identified through a medicinal chemistry programme at the University of Texas Health Science Center as the lead NNMT inhibitor candidate among a series of 1-methylquinolinium analogues bearing primary amine substitutions, selected for its combination of high passive membrane permeability (confirmed in PAMPA assays), high active transport membrane permeability (confirmed in bidirectional Caco-2 cell assays), potent NNMT inhibitory activity, and high selectivity including confirmed absence of inhibitory effects on related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway

Many people describe it as stepping on a sharp pebble or having a bruise deep inside the heel that never seems to heal

the secondary C3-amine derivative intermediate e.g., compound 9) may then be methylated to obtain the desired cation (e.g., compound 1f)

The treatment is painless and typically lasts 30 to 60 minutes