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A Phase-3 randomized clinical trial showed that the efficacy of HSK16149 capsules was superior to placebo in all groups for relieving PDPN and appeared well tolerated

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Keep one leg drawn up more than the other Use your first finger (index finger) or middle finger to push in the suppository Gently push the suppository as far as possible into your back passage, pointed end first Once it is as far as it will go, push it side-ways to make sure it touches the wall of the bowel Lower your legs to a comfortable position whilst the suppository is retained in place Keep the suppository inside you for at least 30 minutes If you feel the suppository might come out straight away: You may not have put it in high enough