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Neurofeedback of slow cortical potentials: neural mechanisms and feasibility of a placebo-controlled design in healthy adults

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While opioids activate brain chemistry related to pleasure and dependence by binding to mu-opioid receptors, acetaminophen primarily reduces pain by blocking cyclooxygenase (COX) enzymes in the brain and spinal cord

Additionally, most studies are open-label and unblinded, raising concerns about bias and limited generalizability