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Science (2020) 367:eaau6977

De Tullio, [email protected] This article was submitted to Plant Metabolism and Chemodiversity, a section of the journal Frontiers in Plant Science Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Bioactivation of 4-ipomeanol by CYP4B1: Adduct Characterization and Evidence for an Enedial Intermediate

Beyond the impact of endothelial damage, peritubular capillary rarefaction, pericyte detachment, nephron loss, interstitial hypoxia, and persistent inflammation, metabolic disturbances in TECsparticularly defective FAO and lipid accumulationhave been identified as key contributors to EMT and the progression of renal fibrosis through maladaptive repair mechanisms (Miguel et al., 2021)