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Phase (approx.) Cagrilintide dose Frequency Weeks 14 0.25 mg Once weekly Weeks 58 0.5 mg Once weekly Weeks 912 1.0 mg Once weekly Weeks 1316 1.7 mg Once weekly Week 17 onward 2.4 mg (max studied) Once weekly This step-wise schedule mirrors the titration used in cagrilintide and CagriSema studies ( Lau et al., Lancet 2021

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DSIP and Pain Management In clinical studies, DSIP administration resulted in a notable reduction in pain levels among patients with various pain syndromes, including migraines, vasomotor headaches, chronic tinnitus, and psychogenic pain attacks 6

Most GI side effects peak during dose escalation phases and improve within 2 to 4 weeks at a stable dose

PMID: 28340339 Chondrocyte senolysis study