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Dosing began at 0.25 mg of each active drug and escalated every four weeks until the full 2.4 mg dose was reached by week 16

Alternative volumes for different resulting concentrations Rule: Higher reconstitution volume = finer measurements at small doses in experiments

Sakuma S., Ishimura M., Yuba Y., Itoh Y., Fujimoto Y

FOXO4-DRI effectively improves vascular function in naturally aging mice FOXO4-DRI has made great progress in anti-aging research, but there has been little research on it in the cardiovascular field, especially in the study of vascular aging

The co-culture system established with MCECs and MPMs is shown in Figure 4D