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Natural coumarin derivatives activating Nrf2 signaling pathway as lead compounds for the design and synthesis of intestinal anti-inflammatory drugs

M.WagenerA.FietzekU

Chronic infection and inflammation can deplete endogenous antioxidants such as glutathione, catalase, and vitamins C and E, resulting in amplification for the oxidative stress and cellular damage, and this may have negative effect by causing damage to the alveolar-capillary membrane which causes increased permeability, pulmonary edema, decreased gas exchange, and prolonged oxidative stress causing inflammation, fibrosis, and long-term lung damage

Cell (2011) 144:64674

Data were analysed by Qlucore software ( Infection with influenza A virus C57BL/6 mice were anaesthetized with isoflurane and infected intranasally with 5 10 3 plaque-forming units (PFU) of influenza A/Puerto Rico/8/1934 virus in 50 l PBS on day 0