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When the plasma iron level meets the systemic iron demand, the liver will increase the secretion of hepcidin into the blood, reducing the plasma iron level and maintaining iron homeostasis in the body (39)

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doi: 10.1210/jc.2010-2905 49 FallahiPFerrariSMRagusaFRuffilliIEliaGPaparoSRet al

A melasma formulation combining hydroquinone, tretinoin, and a corticosteroid