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Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced bloodbrain barrier injury through the Wnt/-catenin signalling pathway

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The light and dark regions represent the PEO-CS-LEV and PLGA-QS phase, respectively, indicating the successful formation of a core/shell structure in the nanofibers derived from immiscibility of the polymer solutions during electrospinning

176 Collectively, these advances underscore a fundamental conceptual shift: proteostasis must now be viewed not as a collection of isolated degradation mechanisms but as a coherent, adaptive, and deeply integrated cellular defense network whose resilience determines disease trajectory