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A variety of reagents, most of which are used in cancer treatment, have recently been found with the ability to modulate the ferroptotic process by directly or indirectly targeting iron metabolism and lipid peroxidation

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Moreover, l-ornithine can be transformed into glutamate semialdehyde by ornithine aminotransferase, and then to glutamate, which removes 1 ammonia molecule

4 Potential interplay and clinical association between F/CRGs in HNSCC therapy 4.1 Chemotherapy and targeted drugs Studies have shown that ferroptosis plays an important role in enhancing the efficacy of chemotherapy for HNSCC and overcoming drug resistance, particularly with alkylating chemotherapeutic agents

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