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The Mn/SAE nanozyme core was synthesized in situ within hollow mesoporous zeolitic imidazolate frame-8 (ZIF-8) nanoparticles, then coated with homologous tumor cell membranes for targeted delivery and subsequently labeled with 131 I using the Chloramine-T method

However, because T cells exhibit tremendous heterogeneity, sophisticated measurement technologies are urgently needed to characterize metabolic profiles (including the expression levels of metabolic genes, the activity of metabolic enzymes and the abundance of metabolites) at single-cell resolution (Table 2) (Fig

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Early exhausted T cells also increase their glycolytic activity during chronic viral infection, whereas terminally exhausted T cells exhibited a decline in their overall metabolic activity, including glycolysis [18]

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