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In some embodiments, the invention encompasses contacting one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy

Increases capillary density in muscle tissue to improve blood flow and nutrient delivery during repair

Standard bone health supplementation supports peptide effects

To prevent autotomy, saturated picric acid was topically applied to the hindlimb 37