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Exposure to ROS (involving H 2 O 2 )/RNS, or to compounds which can generate ROS, can increase the content of GSH by increasing the rate of GSH synthesis (2)

26 In CD patients, ingestion of gluten leads to small intestinal damage, typically leading to malabsorption

This disruption increases neuronal excitability by damaging the activity of sodium and potassium ATP enzymes and decreasing membrane potential (4)

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Recent developments highlight that these materials provide timely mechanical support (e.g., in situ modulus enhancement to mitigate fibrosis) and enable microenvironment-driven sequential therapies, including targeted delivery of anti-inflammatory/pro-regenerative factors, ROS scavenging, inhibition of enzymatic activity, immune microenvironment remodeling, and precise regulation of cell fate via endogenous stem cell recruitment/differentiation and ferroptosis suppression