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10.1016/S0303-7207(96)03969-X

Cooperative binding is at the center of this regulation, whereby the binding of oxygen to one heme group makes the other heme groups in a better position to bind with oxygen (35)

This limitation is expected to be addressed by a dedicated two-phased validation strategy in future work: Phase I Retrospective RNA Validation: This involves prioritizing an intensive search for and inclusion of any suitable independent external RNA-seq cohorts with adequate clinical follow-up data