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In human skin fibroblasts, Nrf2-driven antioxidant enzyme expression translated into: Reduced intracellular ROS Improved mitochondrial membrane potential Protection against senescence-associated cell damage [36] In human gingival and periodontal stem cells, Epitalon significantly reduced aging biomarkers such as p16 and p21, decreased ROS levels, and preserved mitochondrial function, even under stress [42]

Table of Contents Toggle What Is GHK-Cu and Why Accuracy Matters GHK-Cu (glycyl-L-histidyl-L-lysine bound with copper) is a naturally occurring tripeptide found in plasma, saliva, and urine

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Stimulation of this pathway also has potential therapeutic value for the treatment of TBI