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Glutaminase is actively expressed in periportal liver cells, renal epithelial cells, and the central nervous system, which is used to synthesize urea and neurotransmitters

Mitochondria are also involved in apoptosis through the extrinsic pathway, in which the death-inducing signaling complex is formed, leading to activation of caspase-8 and then downstream caspases that target substrates leading to programmed cell death (Vakifahmetoglu-Norberg et al., 2017)

Ikeno H, Tochio T, Tanaka H, Nakata S

Biofloc technology (BFT) in shrimp farming: past and present shaping the future

However, when these conditions remain unresolved, the UPR switches to proapoptotic and inflammatory pathways with persistent accumulation of misfolded proteins promoting cell death ( Indeed, NTZ and its active circulating metabolite tizoxanide directly protect from stress-induced apoptosis and necroptosis to alleviate liver damage in acute-on-chronic liver failure rat model ( Apoe / mice ( In our attempt to scrutinize the hepatoprotective potential of NTZ and the possible implication of ER stress inhibition in our model of MTX-induced hepatotoxicity, we compared NTZ effects to a hepatoprotective NAC with documented ER stress inhibition and with a standard ER stress inhibitor (4-PBA) (Soliman et al., 2019)